This advanced formula contains the clinically-proven 2:1:1 of branched chain amino acids. The majority of all the reputable peer-reviewed studies have demonstrated that a 2:1:1 ratio of Leucine to Valine to Isoleucine formula performs better than a straight Leucine supplement or a non-caloric placebo before and after a workout. The 2:1:1 Ratio is what exists in nature and science continues to prove its stability and efficacy.
For many years leucine, a Branched Chain Amino Acid (BCAA) has repeatedly been shown to stimulate the process of skeletal muscle protein synthesis (MPS) via the mTOR signaling pathway (Tipton 2009, Suryawan 2008, Norton 2006, Shimomura 2006, Anthony 2000). This signaling process sets the stage for the synthesis of skeletal muscle proteins (repair, rebuild, grow), and also the inhibition of muscle protein breakdown. These positive effects have caused additional research to be done that brings clarity to how SRX formulates their BCAA and protein supplements.
• The majority of positive research has been done using a ratio of 2:1:1 for the BCAA’s, respectively leucine, isoleucine and valine (Shimomura 2009, 2010, Tang 2006)
• By looking at studies with whey, casein and total milk proteins we can see that 20-25 grams of protein or 2.0 to 2.5 grams of leucine (dairy proteins are roughly 10% leucine) will maximally stimulate the process of skeletal muscle protein synthesis (MPS) via mTOR
• This is the also the upper limit for adding leucine to dairy proteins or BCAA formulas (Tipton 2009, Pasiakos 2011)
The limiting factor is that once the signaling process has been set in motion, a complete protein or essential amino acid mixture must be co-ingested for any skeletal muscle protein synthesis to occur; “Our results indicate that the whey protein plus leucine in healthy young volunteers results in an anabolic response in muscle that is not greater than the previously reported response to whey protein alone” (Tipton 2009).
Moreover, BCAA formulations that over-emphasize leucine over isoleucine and valine (beyond the 2:1:1 ratio found in nature) are now showing to be problematic. Isoleucine has now been shown to ramp up glucose uptake in muscle (Morato. 2013), making a strong argument for NOT formulating BCAA supplements with unproven ratios.
Intra Edg3 can support peak workout performance and intensity, reduce lactic acid build-up, and promote faster recovery from workouts. Plus, it can increase protein synthesis, build lean muscle, and promote fat burn.